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越来越多的证据表明,重复DNA序列与促进一些人类肿瘤复发的染色体重排有关。在一些染色体异位的断裂点区域有高密度重复DNA,如Alu元件,暗示了这些序列可能提供热点同源重组,可能介导染色体异位过程以及增加其他类型的染色体重排发生的可能性。 Alu核心序列本身已经被认为能够促进DNA链交换和重排,并且它含有与chi(已经证明能够在大肠埃稀菌Coli中刺激tecBCD-介导的重组)惊人相似的序列。已经显示Alu重复与减数分裂细胞产生结构基因突变有关。是由于不规则同源重组和随后发生的缺失和,或重复造成的。
There is growing evidence that repetitive DNA sequences are associated with chromosomal rearrangements that promote some human tumors. High-density repetitive DNA, such as the Alu element, is present in some of the chromosomal ectopic regions of the breakpoint, suggesting that these sequences may provide hot-spot homologous recombination that may mediate the chromosomal ectopic process and increase the likelihood of other types of chromosomal rearrangements. The Alu core sequence itself has been thought to facilitate DNA strand exchange and rearrangement, and it contains surprisingly similar sequences to chi, which has been shown to stimulate tecBCD-mediated recombination in E. coli. It has been shown that Alu duplication is associated with the generation of structural gene mutations in meiotic cells. Is due to irregular homologous recombination and subsequent loss and / or duplication.