万古霉素是糖肽类抗生素,最初广泛用于治疗耐甲氧西林葡萄球菌引起的感染症。用药后不久,就报道万古霉素会引起耳毒性。1958年Geraci等报道1例在治疗的第12天出现轻度耳鸣和耳聋。该病人停药两周后因心脏充血衰竭而死亡,其“中度耳聋”一直持续到生命结束。在该文中作者还提到另1例,大约也是在治疗的第12天出现耳鸣,这位病人是“完全感觉型耳聋”,至于听力是否恢复根本没提。1977年后发表的评论中,Geraci认为由万古霉素引起听力损害的病例少见, Vancomycin is a glycopeptide antibiotic, initially widely used to treat methicillin-resistant staphylococcal infections. Shortly after treatment, vancomycin was reported to cause ototoxicity. In 1958 Geraci et al reported a case of mild tinnitus and deafness on the 12th day of treatment. The patient died of heart failure and congestion after two weeks of withdrawal, and his “moderate deafness” lasted until the end of his life. In this article, the author also mentioned another case, about the tinnitus also appeared on the 12th day of treatment. The patient was “totally deaf.” He did not mention hearing at all. In a commentary published after 1977, Geraci found rare cases of hearing loss caused by vancomycin,