一般认为含有二个甲基的有机磷酸酯如马拉硫磷、甲基对氧磷、乐果和甲氧基内吸磷中毒时，对肟类治疗的拮抗性很大。鉴于肟类的疗效不仅与其本身的重活化能力有关，而且受胆碱酯酶（ＣｈＥ）的抑制程度、老化和自发重活化动力学的影响。本实验对人乙酰胆碱酯酶（ＡＣｈＥ）和丁 Generally considered to contain two methyl organic phosphate esters such as malathion, methyl parathion, dimethoate and methoxy phosphorus poisoning, the antagonism of the oxime treatment. Given that the efficacy of oximes is not only related to their own ability to reactivate, but also to the extent of inhibition of cholinesterase (ChE), aging and spontaneous reactivation kinetics. This experiment on human acetylcholinesterase (AChE) and Ding