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本文的目的是研究短时间高空急性缺氧呼吸反应的规律性。10名健康男性受试者,年龄18～21岁,在低压舱模拟3000～7000米高度上进行两种状态缺氧暴露:安静坐位和25瓦自行车功量计活动(VO_2=700～750ml/min;代谢率为3.3～3.6kcal/min)。在低压舱“上升”条件下P_AO_2和P_B(大气压力)呈正相关,安静状态P_AO_2=0.159×PB-17.315(r=0.999,P<0.01);25瓦活动状态P_AO_2=0.160×P_B-21.961(r=0.998,P<0.01),两者有显著的差异。随着高度上升,V_E、V_T和HR(心率)的增加均和P_AO_2呈指数型相关。可以用传递函数G(S)=K·e-τ·s/(TS+1)来描述安静和轻度活动状态下阶跃性缺氧时P_AO_2和P_B间关系。模型参数K和T存在着个体差异,同时观察到在活动状态下K值减小和T值缩短,本文对K、T值的生理意义进行了讨论。
The purpose of this paper is to study the regularity of short-term altitude hypoxic hypoxia. Ten healthy male subjects, aged 18-21 years, underwent two state hypoxia exposures at a height of 3,000 to 7,000 meters in a low-pressure cabin simulation: quiet sitting and 25-watt bicycle power meter activity (VO_2 = 700-750 ml / min ; Metabolic rate of 3.3 ~ 3.6kcal / min). P_AO_2 and P_B (atmospheric pressure) were positively correlated with P_AO_2 = 0.159 × PB-17.315 (r = 0.999, P <0.01) in the “up” condition of the low-pressure cabin; P_AO_2 = 0.160 × P_B-21.961 = 0.998, P <0.01), there is a significant difference between the two. As the height increased, the increase of V_E, V_T and HR (heart rate) both correlated exponentially with P_AO_2. The transfer function G (S) = K · e-τ · s / (TS + 1) can be used to describe the relationship between P_AO_2 and P_B in a step-wise hypoxia in quiet and mild activity. There are individual differences between the model parameters K and T, meanwhile the K value and the T value shortening are observed in the active state. The physiological significance of K and T values are discussed in this paper.