【摘 要】
：
Surface functionalization is generally accepted as one of the most useful methods for endowing bet-ter biocompatibility of the cardiovascular implants.Chondroitin sulfate (CS) is a commercial drug ap-plied for preventing cardiovascular diseases in clinics
【机 构】
：
Key Lab.for Advanced Technologies of Materials,Ministry of Education,School of Material Science and
论文部分内容阅读
Surface functionalization is generally accepted as one of the most useful methods for endowing bet-ter biocompatibility of the cardiovascular implants.Chondroitin sulfate (CS) is a commercial drug ap-plied for preventing cardiovascular diseases in clinics,suggesting a potential application for func-tionalized coatings.Our previous work demonstrated that the CS conjugated onto the poly-dopamine(PDA)/hexanediamine (HD) co-deposited 316L stainless steel (316L SS) could endow the surface stronger multi-functions for cardiovascular implants.However,the natural CS has two subtypes,CS A and CS C,while it is still unclear which subtype makes more contribution to the surface modification of cardiovas-cular implants.Thus,the present study focus on comparing CS A and CS C via preparing functionalized coatings on the cardiovascular implants.Our data suggested PDA/HD-CS C coating possessed better blood compatibility and pro-endothelialization function through controlling the phenotype and distribution of macrophages,smooth muscle cells and endothelial cells in time sequence and space sequence.
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