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目的 探讨长效达必佳在体外受精 胚胎移植 (IVF ET)中协同超排卵的有效剂量。方法 2 0 0 1年10月至 2 0 0 2年 6月间在同一时期接受IVF ET助孕治疗患者中 ,39例 (观察组 )肌注 1 2 5 0mg长效达必佳 ;38例(对照组 )肌注 1 875mg达必佳。结果 两组在使用促性腺激素 (Gn)前及绒毛膜促性腺激素 (HCG)注射日的黄体生成激素 (LH)水平差异无显著性意义 (P >0 0 5 ) ,两组Gn用量及用药天数差异无显著性意义 (P >0 0 5 ) ,两组的HCG注射日雌二醇 (E2 )水平、子宫内膜厚度、获卵数、受精率、卵裂率差异均无显著性意义 (P >0 0 5 )。结论 1/ 3剂量达必佳和半量达必佳在超促排卵治疗中有相同的治疗效果
OBJECTIVE: To study the effective dosages of long-acting Dabideng in synergistic superovulation in IVF ET. Methods From October 2001 to June 2002, 39 patients (observation group) were given intraperitoneal injection of 1205 mg of long-acting Dabisipede during the same period of IVF ET. 38 Control group) intramuscular injection of 1,875 mg of dabigatran. Results There was no significant difference in LH level between the two groups before Gn administration and HCG injection (P> 0.05). The Gn dosage and medication There was no significant difference between the days (P> 0.05). There was no significant difference in E2 level, endometrial thickness, number of oocytes retrieved, fertilization rate and cleavage rate between the two groups on HCG injection day P> 0 0 5). Conclusions One-third doses of dabigatran and half-dose of dabigatran have the same therapeutic effect in superovulation treatment