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目的探讨缬沙坦联合硝苯地平控释片治疗原发性高血压的临床效果。方法将2016年2月至2017年3月104例原发性高血压患者根据数字表法分组(各52例)。对照组给予缬沙坦治疗,联用组给予缬沙坦联合硝苯地平控释片治疗。比较两组原发性高血压控制效果;不良反应;干预前后患者心率、收缩压监测值、舒张压监测值。结果联用组原发性高血压控制效果高于对照组,P<0.05;两组无明显不良反应。干预前两组心率、收缩压监测值、舒张压监测值相近,P>0.05;干预后联用组心率、收缩压监测值、舒张压监测值低于对照组,P<0.05。结论缬沙坦联合硝苯地平控释片治疗原发性高血压的临床效果确切,可改善血压和心率,无明显副作用,安全有效。
Objective To investigate the clinical effect of valsartan combined with nifedipine in the treatment of essential hypertension. Methods From February 2016 to March 2017, 104 patients with essential hypertension were divided into groups according to the digital table (each 52 cases). The control group was given valsartan, and the combination group was given valsartan combined with nifedipine controlled release tablets. The control effect of primary hypertension was compared between the two groups. Adverse reactions were observed. The heart rate, systolic blood pressure monitoring value and diastolic blood pressure monitoring value before and after intervention were compared. Results The control effect of hypertension in combined group was higher than that in control group (P <0.05). There was no obvious adverse reaction in both groups. Before intervention, heart rate, systolic blood pressure monitoring and diastolic blood pressure monitoring were similar, P> 0.05; after intervention, heart rate, systolic blood pressure monitoring and diastolic blood pressure monitoring were lower than the control group (P <0.05). Conclusion Valsartan combined with nifedipine GITS in the treatment of essential hypertension has definite clinical effect, which can improve blood pressure and heart rate without obvious side effects and is safe and effective.