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ＦＨＩＴ基因定位于３ｐ１４.２，包含ＦＲＡ３Ｂ，ｔ（３；８）断裂点及ＨＰＶ１６整合位点。在许多肿瘤中均出现异常。由于ＦＨＩＴ在肿瘤中的基因改变不同于经典的抑癌基因，因此关于其是否为抑癌基因还存在不同的观点。阐明ＦＨＩＴ基因在肿瘤发生、演变中的作用，有可能为肿瘤的分子生物学研究提供新的思路。
The FHIT gene is located at 3p14.2 and contains the FRA3B, t (3; 8) breakpoint and the HPV16 integration site. Abnormalities occur in many tumors. Because FHITs differ from classical anti-oncogenes in their genetic alterations in tumors, there are different views as to whether they are tumor suppressor genes. To elucidate the role of FHIT in tumorigenesis and evolution, it is possible to provide new ideas for the molecular biology research of tumors.