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目的 :提高目前临床对瑞氏综合征的认识。方法 :对本院 2 0年来收治的 2 3例确诊为瑞氏综合征患儿的一般资料、临床表现、实验室结果及CT和病理资料、预后进行总结与对比。结果 :瑞氏综合征病儿的发病机制中有感染因素的参与 ;农村儿童的发病率远高于城镇儿童 ;好发年龄为 5岁以下儿童 ,尤其 2岁以下儿童多见 ;临床表现以起病急骤、频繁呕吐、迅速出现抽搐或昏迷为特征 ,突出的体征为肌张力增高及呼吸节律异常 ,多伴有肝脏轻度肿大 ,脾不大 ;高血氨为本病的主要临床特点之一。肝穿可提高该病确诊率。结论 :瑞氏综合征患儿发病急 ,死亡率高 ,预后差。
Objective: To improve the current clinical awareness of Reye’s syndrome. Methods: The general data, clinical manifestations, laboratory findings, CT and pathological data of 23 children diagnosed with Reye’s syndrome admitted to our hospital in 20 years were summarized and compared. Results: The pathogenesis of Wright’s syndrome patients was affected by the infection factors. The incidence of rural children was much higher than that of urban children. The incidence of children younger than 5 years old, especially those under 2 years old, was more common. The clinical manifestations were as follows: Rapid onset, frequent vomiting, rapid convulsions or coma is characterized by prominent signs of increased muscle tension and abnormal breathing rhythm, accompanied by a slight enlargement of the liver, spleen is not; high blood ammonia-based clinical features of the disease one. Liver wear can improve the diagnosis of the disease. Conclusion: Children with Reye’s syndrome have acute onset and high mortality rate and poor prognosis.