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Cu-TiO_2 catalysts supported onγ-Al_2O_3 are prepared and used in glycerol cyclization with 1,2-propanediamine to produce pyrazinyl compounds including 6-hydroxymethyl-2-methylpyrazine,5-hydroxymethyl -2-methyIpyrazine,2,6-dimethylpyrazine and 2,5-dimethylpyrazine in a fixed-bed system.It is found that glycerol cylclization with 1,2-propanediamine gave a high total yield of pyrazinyl compounds(>80%) over Cu-Ti02/γ-Al_2O_3 catalyst,and cyclization was through the reactions between activated 1,2-propanediamine and the intermediates from glycerol dehydration and oxidation.In addition,the regioselectivity of the pyrazinyl compounds was mainly controlled by the steric hindrance of the substrates during the cyclization process.
Cu-TiO 2 catalysts supported on γ-Al 2 O 3 are prepared and used in glycerol cyclization with 1,2-propanediamine to produce pyrazinyl compounds including 6-hydroxymethyl-2-methylpyrazine, 5-hydroxymethyl- 5-dimethylpyrazine in a fixed-bed system. It is found that glycerol cylclization with 1,2-propanediamine gave a high total yield of pyrazinyl compounds (> 80%) over Cu-Ti02 / γ-Al 2 O 3 catalyst, and cyclization was through the reactions between activated 1,2-propanediamine and the intermediates from glycerol dehydration and oxidation. In addition, the regioselectivity of the pyrazinyl compounds was mainly controlled by the steric hindrance of the substrates during the cyclization process.