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近二十年来,人们才真正认识到某些药物能引起胎儿的畸形(致畸)。1956年西德一药厂生产了。一种新的安眠药——反应停(thalidomide),这是一种中枢神经镇静剂,后来用为抗麻风反应药。这种药物按常规的毒理学方法测定认为是安全的。小鼠口服该药LD_(50)大于5g/kg。在偶然的事故中也肯定了反应停的安全性,有几个服过量反应停妄图自尽的人,也未引起严重的急性毒性反应。因此药厂成批生产,供应市场,但是没有预料到该药却具有强烈的致畸作用,仅在药物问世后的两年内,服药孕妇中就生出了8000个畸形胎儿。在如此短时期内大量畸形胎儿的出生,引起了临床专家、药物学家和遗传学家的重视,此后世界上20余
In the past two decades, people really realized that certain drugs can cause fetal deformity (teratogenicity). 1956 West Germany a pharmaceutical production. A new sleeping drug, thalidomide, is a central tranquilizer that was later used as an anti-leprosy medication. The drug is considered safe by conventional toxicological methods. Mice received oral LD_ (50) greater than 5g / kg. In the accident also affirmed the safety of the reaction stop, there are a few overdose to stop trying to halt themselves, nor caused serious acute toxicity. Therefore, the pharmaceutical factory mass production, supply market, but did not expect the drug has a strong teratogenic effect, only two years after the advent of drugs, giving birth to pregnant women in the 8000 abnormal fetus. In such a short period of time a large number of deformed fetuses born, attracted the attention of clinical experts, pharmacologists and geneticists, since the world more than 20