双肼酞嗪与硫酸成盐即为高血压用药,商品名为“血压达静”。此药作为复方降压药,疗效较好,但由于此药单独使用时的副作用和生产工艺复杂,在我国只有个别工厂间断生产。近年来,国外研究逐渐增多,日本更合成了它的一些衍生物,其降压作用引起了人们的兴趣。为此我们试图简化原工艺步骤,探讨新的工艺路线。原来的工艺路线须由1,4-二氯酞嗪经甲氧基化,得到1-氯-4-甲氧基酞嗪,再肼化得1,4-双肼酞嗪,反 Double hydrazine phthalazine and sulfuric acid salt is hypertensive medication, trade name “blood pressure up to static ”. The drug as a compound antihypertensive drugs, better efficacy, but because of side effects of this drug when used alone and the complexity of the production process, in our country only intermittent production of individual plants. In recent years, foreign studies have gradually increased, and Japan has even synthesized some of its derivatives, and its antihypertensive effect has aroused people’s interest. To this end, we try to simplify the original process steps to explore new process routes. The original process route must be by 1, 4-dichlorophthalazine methoxylation to give 1-chloro-4-methoxy phthalazine, and then hydrazine to 1,4-bis-hydrazine phthalazine, anti