依托考昔是一类新型特异性COX-2抑制剂,目前被广泛应用于痛风性关节炎和其他骨关节炎的抗炎、镇痛治疗。依托考昔明显减少了非甾体抗炎药(NSAIDs)的常见不良反应,包括消化道黏膜损伤、肝肾毒性、变态反应及血液系统异常等。但其仍可引起消化道溃疡、心血管损害以及肾功能损害等[1-2]。血小板减少是依托考昔少见的不良反应,现将1 Etoposide is a new type of specific COX-2 inhibitor currently used in anti-inflammatory and analgesic treatment of gouty arthritis and other osteoarthritis. Etoploxetil significantly reduced the common side effects of NSAIDs, including mucosal lesions of the digestive tract, liver and kidney toxicity, allergic reactions, and abnormalities in the blood system. But it can still cause gastrointestinal ulcers, cardiovascular damage and renal dysfunction [1-2]. Thrombocytopenia is based on rare adverse reactions, now 1