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纤溶酶原激活抑制剂(plasminogenactivatorinhibi tor1,PAI1)可阻断纤溶系统使血栓难以溶解。糖耐量异常时血PAI1水平开始上升。PAI1在血栓形成过程中起关键作用,血PAI1水平与发生心血管意外有很强的相关性。PAI1生成受肿瘤坏死因子(TNFα)和氧化应激调控,被认为是与代谢综合征
Plasminogen activator inhibitor (PAI1) blocks the fibrinolysis system and renders the thrombus difficult to dissolve. Blood levels of PAI1 begin to rise during impaired glucose tolerance. PAI1 plays a key role in the thrombosis process. There is a strong correlation between PAI1 level and cardiovascular accident. PAI1 production is regulated by tumor necrosis factor (TNFα) and oxidative stress and is thought to be associated with metabolic syndrome