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目的探讨PAPP-A在妇产科妊娠期高血压疾病发病中的应用价值。方法采用酶联免疫吸附法分别测定对照组60例正常孕妇和60例妊娠期高血压疾病孕妇(其中妊娠期高血压30例,子痫前期20例,子痫10例)血清中PAPP-A水平,并进行比较。结果子痫前期、子痫患者PAPP-A水平显著高于对照组(P<0.01)。结论 PAPP-A可用于妊娠期高血压临床的检测和评估,通过分析患者血清中PAPP-A水平的变化,能有效了解患者的病情阶段及其变化情况,PAPP-A在妇产科妊娠期高血压疾病发病中具有极高的临床应用价值。
Objective To investigate the value of PAPP-A in the pathogenesis of hypertensive disorders in pregnancy and obstetrics. Methods The levels of PAPP-A in serum of 60 normal pregnant women and 60 pregnant women with hypertensive disorder complicating pregnancy (including 30 cases of gestational hypertension, 20 cases of preeclampsia and 10 cases of eclampsia) were determined by enzyme-linked immunosorbent assay (ELISA) , And compare. Results The levels of PAPP-A in preeclampsia and eclampsia were significantly higher than those in control group (P <0.01). Conclusions PAPP-A can be used in the detection and evaluation of clinical pregnancy-induced hypertension. PAPP-A can be used to understand the stage of disease and its changes in PAPP-A patients by analyzing the change of PAPP- The incidence of blood pressure disease has a very high clinical value.