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NO是由L-精氨酸在NO合成酶作用下产生的,具有很强的反应活性的自由基气体,参与了神经传导、血压的调控。在肾脏NO可调节入球动脉张力及肾小球系膜细胞的增殖,近期研究还表明NO参与了大鼠肾炎模型的损伤过程,如由抗胸腺细胞抗体诱导的大鼠系膜增殖性肾炎,抑制NO合成酶可减少尿蛋白排泄量及系膜基质的扩张等。NO性质极为活泼,体内可迅速分解为NO_2~-/NO_3~-,后者性质稳定,可代表体内NO代谢情况,本文以镉柱比色
NO is produced by L-arginine under the action of NO synthase and has a strong reactive free radical gas, which is involved in the regulation of nerve conduction and blood pressure. NO in the kidneys can regulate the intima-media tension and glomerular mesangial cell proliferation, recent studies have also shown that NO involved in the injury model of rat nephritis, such as anti-thymocyte antibody-induced rat mesangial proliferative glomerulonephritis, Inhibition of NO synthase can reduce urinary protein excretion and mesangial matrix expansion. The nature of NO is very lively, the body can be quickly decomposed into NO_2 ~ - / NO_3 ~ -, the latter is stable and can represent NO metabolism in vivo. In this paper,