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目的:分析药物不良反应发生特点、注意事项、临床表现和治疗,为临床合理用药提供参考。方法:随机抽取河南省人民医院2009年度药物不良反应报告100份,借助统计学方法进行归纳和分析。结果:药物不良反应涉及药品60种,其中抗感染药物11种,占药品总数18%,占病例总数29%;中成药12种,占药品总数20%,占病例总数25%;给药途径以静脉滴注为主,占91%;老年患者易发生药物不良反应;常见不良反应为皮肤及其附件损伤;严重药物不良反应占5%。结论:药物不良反应发生与多种因素有关,加强药物不良反应监测工作有助于减少药物不良反应发生。
Objective: To analyze the characteristics of adverse drug reactions, precautions, clinical manifestations and treatment, provide a reference for clinical rational use of drugs. Methods: A total of 100 random reports of adverse drug reactions in 2009 from Henan Provincial People’s Hospital were collected and statistically analyzed. Results: The adverse drug reactions involved 60 kinds of drugs, of which 11 kinds of anti-infective drugs, accounting for 18% of the total number of drugs, accounting for 29% of the total number of cases; 12 kinds of proprietary Chinese medicines, accounting for 20% of the total number of drugs, accounting for 25% of the total number of cases; Intravenous drip-based, accounting for 91%; Elderly patients prone to adverse drug reactions; common adverse reactions for the skin and its attachment damage; serious adverse drug reactions accounted for 5%. Conclusion: Adverse drug reactions occur with a variety of factors, and strengthening the monitoring of adverse drug reactions can help reduce adverse drug reactions.