TNF相关的凋亡诱导配体 (TRAIL)及其受体 (TRAILR)是近年来很受关注的一组凋亡相关分子 ,目前发现的该家族成员包括TRAIL和它的四个受体。恶性黑素瘤细胞表面表达TRAIL和TRAILR ,并可以被其诱导凋亡。由于TRAIL仅能诱导转染细胞或肿瘤细胞凋亡 ,对正常的细胞没有细胞毒作用 ,因此在恶性黑素瘤的治疗中具有良好的应用前景。 TNF-related apoptosis-inducing ligands (TRAILRs) and their receptors (TRAILRs) are a group of apoptosis-related molecules that have attracted much attention in recent years. Currently, members of this family are TRAIL and its four receptors. Malignant melanoma cells express TRAIL and TRAILR on their surface and can induce apoptosis. Because TRAIL can only induce the apoptosis of transfected cells or tumor cells and has no cytotoxic effect on normal cells, TRAIL has good application prospect in the treatment of malignant melanoma.