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非溃疡性消化不良(non-ulcer dyspepsia,NUD),又称功能性消化不良(functional dyspepsia,FD),是一种常见的临床病症。其病因、病理生理机制仍不清楚,近年研究显示其发病与胃酸、胃肠动力障碍、幽门螺杆菌感染及心理等因素相关。国内外均提出了非溃疡性消化不良的诊疗流程。目前该病的诊断主要是排除性诊断,治疗以经验性治疗为主,临床疗效尚不理想,是否需根除幽门螺杆菌尚有争议。因此,如何评价FD治疗中抗酸剂、抑酸剂、促动力剂及根除幽门螺杆菌等的疗效是许多医生关注的问题。以下的系统评价从非溃疡性消化不良的诊治策略、药物治疗及根除幽门螺杆菌等方面进行了评估,可作为临床诊疗时参考。治疗时需考虑疗效价格比并应重视心理治疗。
Non-ulcer dyspepsia (NUD), also known as functional dyspepsia (FD), is a common clinical condition. The etiology, pathophysiology remains unclear, recent studies have shown that the incidence of gastric acid, gastrointestinal motility disorders, Helicobacter pylori infection and psychological factors. At home and abroad have proposed non-ulcer dyspepsia diagnosis and treatment process. Currently the diagnosis of the disease is mainly excluded from the diagnosis and treatment based on empirical treatment, clinical efficacy is not ideal, whether the need to eradicate Helicobacter pylori is still controversial. Therefore, how to evaluate the efficacy of antacids, antacids, promoters and the eradication of Helicobacter pylori in FD treatment are the concerns of many doctors. The following systematic reviews evaluated the diagnosis and treatment strategies for non-ulcer dyspepsia, drug therapy and the eradication of Helicobacter pylori, which can be used as reference in clinical diagnosis and treatment. Treatment should consider the cost-effective and should pay attention to psychological treatment.