泰素(Taxol),商品名Paclitaxel,是从太平洋紫杉属树皮提出的新型较广谱的抗肿瘤药物,其主要作用机制为通过与微管蛋白结合,提高微管的聚合作用,并稳定已形成的微管,从而抑制微管以正常的动力学方式重组及细胞的复制,作用于细胞增殖周期的G_2期及M期,从而杀伤瘤细胞。大多数文献报道它与顺铂或卡铂类药物联合应用于治疗成人晚期卵巢癌、乳腺癌、非小细胞性肺癌等,具有一定疗效,但在小儿难治性恶性肿瘤中的应用报道不多。我院自1994年10月～1995年5月,应用以泰素为 Paclitaxel, a new broad-spectrum anticancer drug derived from the Pacific yew tree bark, is mainly used by Taxol, which enhances the polymerization of microtubules and stabilizes the microtubules by binding to tubulin Has formed microtubules, thereby inhibiting microtubules in the normal kinetic recombination and cell replication, the role of cell cycle in the G2 phase and M phase, thus killing the tumor cells. Most of the literature reports that it has a certain curative effect in combination with cisplatin or carboplatin in the treatment of advanced ovarian cancer, breast cancer and non-small cell lung cancer in adults, but it has not been reported in refractory malignant tumors in children . Our hospital from October 1994 to May 1995, the application of Tai Sui