“手、足、病”是由Robinson于1957年首先描述并予命名。当时在加拿大的多伦多地区流行着一种有皮肤发疹伴有咽部损害的热性病,Robinson在71％的病例中分离得Coxsackie A16病毒,从而确立了此病。此后,各国均有关于本病的报道,但为数不多。本文作者报道了自己所见的两例,并对本病作了较系统的复习。临床表现: “手、足、病”是一种季节性、流行性、发疹性热病,主要侵犯幼儿(半数患者在5岁以下,不拘性别),但也能发生于成年人,作者报道的两例即为成人。本病的传染性极强,在儿童之间常由口腔传染。 “Hand, Foot and Sickness” was first described and named by Robinson in 1957. At that time a hot skin disease with skin lesions and pharyngeal lesions was prevalent in Toronto, Canada, and Robinson established Coxsackie A16 virus in 71% of cases. Since then, all countries have reported this disease, but few. The authors reported two cases they had seen and made a systematic review of the disease. Clinical manifestations: “Hand, foot, and sickness” is a seasonal, epidemic, rash fever that mainly affects young children (half of whom are under 5 years of age, regardless of gender) but can also occur in adults, the authors report The two cases are adults. The disease is extremely contagious, often in children between the oral infection.