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目的观察抗高血压药物联合瑞舒伐他汀钙对原发性高血压患者的血脂指标、颈动脉内膜-中层厚度(CIMT)和颈动脉斑块总积分的影响。方法收集2015年1月至2016年1月在西安交通大学医院诊治的58例原发性高血压患者,根据用药不同分为2组,其中对照组28例,采用单纯抗高血压药物治疗;观察组30例,采用抗高血压药物联合瑞舒伐他汀钙治疗。比较2组患者在治疗前和治疗后12、24、40周的血脂指标,CIMT,颈动脉斑块总积分。结果与对照组比较,观察组患者在治疗12、24、40周后,胆固醇(CHO),低密度脂蛋白胆固醇(LDL-C),载脂蛋白B(Apo B)均明显降低,差异有统计学意义(P<0.05);在治疗24、40周后,观察组患者的CIMT和颈动脉斑块总积分均明显降低,差异有统计学意义(P<0.05)。与治疗12周比较,在治疗40周后,观察组患者的CHO、LDL-C、Apo B均明显降低,差异有统计学意义(P<0.05)。与治疗12周比较,在治疗24、40周后,观察组患者的CIMT和颈动脉斑块总积分均明显降低,差异有统计学意义(P<0.05)。与24周比较,在治疗40周后,观察组患者的CIMT和颈动脉斑块总积分均明显降低,差异有统计学意义(P<0.05)。结论长期抗高血压药物联合瑞舒伐他汀钙治疗原发性高血压,可以明显降低血脂指标和CIMT,改善颈动脉斑块。
Objective To investigate the effects of antihypertensives combined with rosuvastatin calcium on serum lipid, carotid intima - media thickness (CIMT) and total carotid plaque score in patients with essential hypertension. Methods Fifty-eight patients with primary hypertension diagnosed and treated in Xi’an Jiao Tong University Hospital from January 2015 to January 2016 were divided into two groups according to the different medication, including 28 cases in the control group, treated with antihypertensive drugs alone. Group of 30 patients with antihypertensive drugs combined with rosuvastatin calcium treatment. The blood lipid level, CIMT and total carotid plaque score were compared between the two groups before and 12, 24 and 40 weeks after treatment. Results Compared with the control group, the levels of cholesterol (CHO), low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (Apo B) in the observation group were significantly decreased after treatment for 12, 24 and 40 weeks (P <0.05). After 24 and 40 weeks of treatment, the total score of CIMT and carotid artery plaque in the observation group were significantly decreased, with statistical significance (P <0.05). Compared with the 12-week treatment, the levels of CHO, LDL-C and Apo B in the observation group decreased significantly after 40 weeks of treatment, with statistical significance (P <0.05). Compared with the 12-week treatment, the total score of CIMT and carotid artery plaque in observation group decreased significantly after 24 and 40 weeks of treatment, with statistical significance (P <0.05). Compared with 24 weeks, the total score of CIMT and carotid plaque in observation group decreased significantly after 40 weeks of treatment, with statistical significance (P <0.05). Conclusion Long-term antihypertensive drugs combined with rosuvastatin calcium in the treatment of essential hypertension can significantly reduce blood lipid and CIMT, improve carotid plaque.