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目的检测并分析尘肺患者血清中白细胞介素-6和C-反应蛋白含量变化,为尘肺病的诊断、分期以及防治工作提供依据。方法采用免疫透射比浊法对住院不同期别尘肺患者(病例组)94例以及未接触过粉尘作业门诊体检人员(对照组)30人进行白细胞介素-6和C-反应蛋白的测定和分析。结果与对照组相比,尘肺患者血清中白细胞介素-6与C-反应蛋白水平均明显升高(P<0.05);与对照组相比,Ⅰ期、Ⅱ期、Ⅲ期尘肺患者白细胞介素-6和C-反应蛋白含量有递增的趋势,各组间差异有统计学意义(P<0.05)。结论尘肺患者血清中白细胞介素-6和C-反应蛋白升高对尘肺患者临床诊断、分期,预后以及尘肺病发病机理的探讨有一定的意义。
Objective To detect and analyze the changes of serum interleukin - 6 and C - reactive protein in patients with pneumoconiosis and provide basis for the diagnosis, staging and prevention and control of pneumoconiosis. Methods Immuno-turbidimetry was used to detect and analyze the levels of interleukin-6 and C-reactive protein in 94 patients with pneumoconiosis (case group) and 30 patients without contact with dust clinic (control group) . Results Compared with the control group, the levels of IL-6 and C-reactive protein in patients with pneumoconiosis were significantly increased (P <0.05). Compared with the control group, the level of interleukin 6 and C-reactive protein content has an increasing trend, the difference between the groups was statistically significant (P <0.05). Conclusions Elevated interleukin-6 and C-reactive protein levels in patients with pneumoconiosis have clinical significance in the clinical diagnosis, staging, prognosis and the pathogenesis of pneumoconiosis.