TRAIL〔TNF相关细胞诱导配体 (TNF relatedapoptosis inducingligand)〕是新近发现的一类能选择性诱导肿瘤细胞或转化细胞发生凋亡的配体 ,其诱导肿瘤细胞发生凋亡是依赖多种细胞因子及通过多种途径的。但越来越多的研究表明 ,有相当多的肿瘤细胞株对TRAIL并不敏感 ,采用药物干预的方法 ,能提高TRAIL诱导肿瘤细胞的凋亡作用 TRAIL (TNF related cell inducing ligand) is a recently discovered class of ligands that selectively induce apoptosis in transformed or transformed cells. The induction of apoptosis by tumor cells is dependent on a variety of cytokines and Through a variety of ways However, more and more researches show that a considerable number of tumor cell lines are not sensitive to TRAIL. The drug intervention can increase the apoptosis of TRAIL-induced tumor cells