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目的:分析肝硬化患者出现上消化道出血与细菌感染之间的相关性。方法:选取东莞大朗医院收治的135例肝硬化患者的临床资料进行回顾性分析,其中,上消化道出血细菌感染患者66例,将其列入观察组,同时将69例无细菌感染患者列入对照组。对比两组症状和表现以及出血情况的具体差异性。结果:观察组共检出69株病原菌,其中含有44株(63.7%)细菌,进一步分析患者的感染部位可见,肺炎、菌血症、尿路感染以及自发性腹膜炎比较,差异无统计学意义(P>0.05);观察组的Child分级平均积分是(11.3±2.4)分,对照组的Child分级平均积分是(9.1±2.1)分,差异具有统计学意义(P<0.05);观察组再出血率是51.5%,4周内病死率是39.4%,对照组再出血率是30.4%,4周内病死率是15.9%,差异具有统计学意义(P<0.05)。结论:针对肝硬化上消化道出血患者而言,若出现细菌感染合并症,那么其肝脏损害程度会加重,这就会显著地降低患者的生存率,因此要高度重视做好感染的防治工作。
Objective: To analyze the correlation between upper gastrointestinal bleeding and bacterial infection in cirrhotic patients. Methods: A retrospective analysis was performed on the clinical data of 135 patients with cirrhosis admitted to Dalang Hospital of Dongguan. Among them, 66 cases of upper gastrointestinal bleeding bacterial infection were included in the observation group, and 69 cases of patients without bacterial infection Into the control group. Compare the two groups of symptoms and manifestations and the specific differences in bleeding. Results: A total of 69 pathogenic bacteria were detected in the observation group, including 44 (63.7%) bacteria. Further analysis showed that there were no significant differences in pneumonia, bacteremia, urinary tract infection and spontaneous peritonitis P> 0.05). The average score of Child in the observation group was (11.3 ± 2.4) points, while that in the control group was (9.1 ± 2.1) points, the difference was statistically significant (P <0.05) The rate of death was 51.5%. The case fatality rate was 39.4% in 4 weeks, the rate of rebleeding in control group was 30.4%, and the case fatality rate in 4 weeks was 15.9%. The difference was statistically significant (P <0.05). Conclusion: For patients with liver cirrhosis who have upper gastrointestinal bleeding, if bacterial infection complications occur, the extent of liver damage will be aggravated, which will significantly reduce the survival rate of patients. Therefore, we should attach great importance to prevention and treatment of infections.