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粗壮女贞叶提取物静脉注射0．098、0．140和0．200g／kg可使麻醉大鼠的血压显著下降，峰值下降37．7％、38．6％和50．2％：灌胃给药（ig）1．36g／kgqd×3d，不影响清醒大鼠的血压。清醒自发性高血压大鼠ig1．08和2．16g／kgqd×5d，血压由24．3±0．5和24．3±0．6降至18．1±0．9和16．6±0．7kPa，降压作用显著（P＜0．001，＜0．001）；对清醒二肾-夹型高血压大鼠，ig粗壮女贞0．5g／kgqd×7d，血压由20．3±3．9降至16．2±3．9kPa，血压下降20％。以上结果提示具有降压作用。昆明小鼠急性毒性试验，ig49g／kg10d内动物生长良好，未出现死亡；腹腔注射5个剂量组（每组10只）按简化机率单位法测得LD502．64±0．21g／kg（P＝0．95）。
Intravenous injection of 0.098, 0.140, and 0.200 g/kg V. sinensis leaves extracts significantly reduced blood pressure in the anesthetized rats, with a peak drop of 37.7%, 38.6%, and 50.2%: gavage Dosing (ig) 1.36g/kg qd x 3d did not affect blood pressure in conscious rats. Awake spontaneously hypertensive rats ig1.08 and 2.16g/kgqd×5d, blood pressure decreased from 24.3±0.5 and 24.3±0.6 to 18.1±0.9 and 16.6± 0.7kPa, antihypertensive effect was significant (P<0.001, <0.001); for awake two kidney-clip hypertensive rats, ig thick privet 0.5g/kgqd×7d, blood pressure by 20.3 From 3.9 to 16.2±3.9kPa, blood pressure dropped by 20%. The above results suggest that there is a hypotensive effect. Kunming mice acute toxicity test, ig49g/kg within 10d animal growth was good, no death; intraperitoneal injection of 5 dose groups (10 per group) measured by the simplified chance unit method LD502.64 ± 0.21g/kg (P = 0.95).