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近年,慢性丙型肝炎的干扰素(IFN)疗法较为盛行,副作用亦有不少报告.作者报告1例慢性丙肝患者使用IFN后出现显著淋巴细胞减少,并因免疫机能不全导致难治性真菌性肺炎的患者.患者男,63岁,1985年患慢性肝炎,HCV抗体阳性,经肝活检诊断为丙型慢性活动性肝炎.给予天然型IFNal×10~6U,1次/d,共2周,而后改为3次/周,共26次,总量为156×10~6U时,出现不安,呈兴奋状态,疑IFN副作用而入院.入院时淋巴细胞为18%(使用IFN前为33%).GPT值从139U降到14U.入院后即停用IFN,经观察精神症状无改善,从第5病日开始给予抗精神药物.几乎在同时
In recent years, interferon (IFN) therapy for chronic hepatitis C has prevailed and there are many reports of side effects. The authors report a significant lymphopenia in patients with chronic hepatitis C after treatment with IFN and refractory fungi due to immunocompromised patients Pneumonia patients, male, 63 years old, suffering from chronic hepatitis, HCV antibody positive in 1985, was diagnosed as chronic active hepatitis C by liver biopsy.If the natural type IFNal × 10 ~ 6U, 1 times / d, a total of 2 weeks, And then changed to 3 times / week, a total of 26 times, a total of 156 × 10 ~ 6U, uneasy, was excited, suspected IFN side effects and admitted to hospital admission lymphocytes 18% (33% before IFN) .GPT value dropped from 139U to 14U. IFN was deactivated after admission, no improvement in psychiatric symptoms was observed, and antipsychotics were given starting on day 5. Almost simultaneously