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本文采用比色法、双抗体夹心ELISA法检测48例病毒性心肌炎患儿及25例正常健康儿血清-氧化氮(NO)、肿瘤坏死因子(TNF)浓度。结果显示:病毒性心肌炎患儿急性期血清NO、TNF(74.57±15.26μmol/L、37.41±15.68ng/ml)均高于正常对照组(25.09±5.54μmol/L、8.23±2.79ng/ml);恢复期呈下降趋势(35.48±9.89μmol/L、15.83±9.69ng/L),但仍高于对照组,有显著性差异(P<0.01),NO与TNF呈显著正相关(P<0.05)。提示;血清NO和TNF水平与病毒性心肌炎的发生发展有关。
In this study, 48 patients with viral myocarditis and 25 healthy controls were assayed for serum nitric oxide (NO) and tumor necrosis factor (TNF) using colorimetric and sandwich ELISA. The results showed that serum levels of NO and TNF in children with viral myocarditis (74.57 ± 15.26μmol / L, 37.41 ± 15.68ng / ml) were significantly higher than those in normal controls (25.09 ± 5.54μmol / L, 8.23 ± 2.79ng / ml) (P <0.05); the recovery period showed a downward trend (35.48 ± 9.89μmol / L, 15.83 ± 9.69ng / L), but still higher than the control group ). Tip; serum NO and TNF levels and the occurrence and development of viral myocarditis.