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目的探讨北京市社区中老年人群高尿酸血症的患病率现状,以及高尿酸血症与其他心血管危险因素的相关性。方法对北京市西罗园社区45～75岁居民采用整群随机抽样的方法抽取762名居民,进行问卷调查、体格检查和实验室检查。结果本社区中老年居民高尿酸血症患病率为16.8%;45～55岁年龄组与56～75岁年龄组高尿酸血症的患病率分别为12.2%和19.9%,差异具有统计学意义(P<0.05)。高尿酸组与正常尿酸组患者相比,血浆尿酸水平具有显著差异(P<0.05),且血浆尿酸水平与高敏C反应蛋白、总胆固醇呈显著正相关(P<0.05)。结论随着年龄的增长,高尿酸血症患病率明显升高;尿酸水平升高与主要心血管危险因素之间呈正相关。
Objective To investigate the prevalence of hyperuricemia in middle-aged and elderly people in Beijing and the correlation between hyperuricemia and other cardiovascular risk factors. Methods Residents aged 45-75 years in Xiluoyuan Community of Beijing adopted a cluster sampling method to select 762 residents for questionnaire survey, physical examination and laboratory examination. Results The prevalence of hyperuricemia in middle-aged and elderly residents in this community was 16.8%. The prevalence rates of hyperuricemia in 45-55-year-old group and 56-75-year-old age group were 12.2% and 19.9% respectively. The difference was statistically significant Significance (P <0.05). There were significant differences in plasma uric acid levels between high uric acid group and normal uric acid group (P <0.05), and plasma uric acid level was positively correlated with high sensitivity C-reactive protein and total cholesterol (P <0.05). Conclusions With the increase of age, the prevalence of hyperuricemia is obviously increased. The increase of uric acid level is positively correlated with the major cardiovascular risk factors.