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如果生物组织中存在稳定的气泡,则声强低于空化阈值的超声波即可引起非热致的一些重要的生物效应。为深入了解其机理及评估其对医学超声技术安全性的关系,生物悬浮液常被用于低声强生物效应的研究。要在悬浮液内产生稳定气泡,可置一具有含气微孔的疏水薄膜于悬浮液中。本文研究在直径为3.7μm的微孔薄膜附近,由1.9MHz超声波所引起犬血球(密度为0.5％)的溶血现象,随生物物理环境的变化。 实验中,考虑到微孔结构(直径3.7μm,长12μm)的共振频率,超声波频率选在1.9MHz。一个高3.2mm,直径22.5mm的样品室被置于离换能器14cm
If there are stable bubbles in the biological tissue, ultrasound with a sound intensity below the cavitation threshold can cause some non-thermal important biological effects. In order to understand its mechanism and assess its relationship with the safety of medical ultrasound technology, biological suspensions are often used in the study of low-sounding and strong biological effects. To create a stable bubble in the suspension, place a hydrophobic membrane with gas-containing micropores in the suspension. In this paper, the hemolysis of canine blood cells (density of 0.5%) caused by 1.9MHz ultrasonic waves near the microporous film with the diameter of 3.7μm was studied with the change of the biophysical environment. In the experiment, taking into account the resonant frequency of the microporous structure (diameter 3.7 μm, length 12 μm), the ultrasonic frequency was chosen to be 1.9 MHz. A sample chamber 3.2 mm in height and 22.5 mm in diameter was placed 14 cm from the transducer