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在对人体和实验动物肺动脉高压病理形态学观察的基础上,选择肺血管平滑肌细胞(PASMC)的增生和细胞表型转化为本课题攻关的突破口。应用肺血流动力学、形态计量学、免疫细胞化学、形态学(光镜、电镜)等观察方法,动态观察实验大鼠腺泡内肺动脉(IAPA)段的构型改变与肺动脉高压发生之间的关系。发现IAPA管壁增厚、管腔变狭、无肌动脉数量减少、肌型动脉数目增多等项改变,都与肺动脉压力的升高呈线性相关,相关系数0.70～0.85。同时发现:(1)IAPA内皮细胞可能是缺氧和炎症损伤的
On the basis of observing the pathomorphology of pulmonary hypertension in human and experimental animals, the proliferation and phenotype of pulmonary vascular smooth muscle cells (PASMC) were selected as the breakthrough point for this topic. The pulmonary artery hemodynamics, morphometry, immunocytochemistry, morphology (light microscopy, electron microscopy) and other observation methods were used to dynamically observe the change of configuration of pulmonary artery (IAPA) Relationship. Found IAPA wall thickening, narrowing of the lumen, no decrease in the number of muscular arteries, the increase in the number of muscular arteries and other items, and pulmonary artery pressure was linearly correlated with a correlation coefficient of 0.70 ~ 0.85. Also found: (1) IAPA endothelial cells may be hypoxic and inflammatory damage