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为研究低浓度(1mg/m~3)晶体石英粉尘与矽肺发病的关系,我们采用雄性Wistar大白鼠经动式吸入染尘历时一年另三个月。结果发现实验组动物全肺胶原蛋白含量均高于对照组(P<0.01),且随染尘时间的延长而增长。病理组织学观察有矽尘反应性慢性支气管炎、肺硬化及细胞纤维性结节等矽肺早期表现。实验结束时石英尘在鼠肺组织中的平均沉积量为0.91863mg.占粉尘总吸入置的3.92％。研究表明,我国现行石英粉尘最高容许浓度(总尘)1mg/m~3是可行的,但从长远看仍有一定危险性。作者建议吸入性石英粉尘的最高容许浓度以0.35mg/m~3为宜。
In order to study the relationship between the low concentration (1mg / m ~ 3) crystalline quartz dust and the incidence of silicosis, we used a male Wistar rat to inhale the dust for one year and three months. The results showed that the content of collagen in the whole lung of the experimental group was higher than that of the control group (P <0.01), and increased with the prolongation of the dust time. Histopathological observation of silica-reactive chronic bronchitis, pulmonary sclerosis and fibrous fibrosis nodules and other early manifestations of silicosis. At the end of the experiment, the average deposition of quartz dust in rat lung tissue was 0.91863 mg, accounting for 3.92% of the total inhaled dust. The research shows that the maximum allowable concentration of dust (1mg / m ~ 3) in China is practicable, but there is still some danger in the long run. The authors recommend inhalation of quartz dust maximum allowable concentration of 0.35mg / m ~ 3 is appropriate.