论文部分内容阅读
免疫缺陷是指机体免疫系统发育缺陷或免疫应答障碍。免疫缺陷可发生于免疫系统的各个部分。例如在非特异性免疫中,可有补体缺陷和吞噬细胞减少或功能低下;在特异性免疫中则可有细胞免疫缺陷或体液免疫缺陷,严重者可有联合免疫缺陷。这些先天性和继发性免疫缺陷,使机体对外来的病原体不能产生正常的免疫应答,不能防止病原体对机体的侵入和控制疾病的发展。因此,反复感染或严重感染就成为免疫缺陷患儿最明显的临床表现,也是死亡的主要原因。
Immunodeficiency refers to the development of the body’s immune system defects or immune response disorders. Immunodeficiency can occur in various parts of the immune system. For example, in nonspecific immunity, there may be complement defects and phagocyte reduction or dysfunction; in specific immunity may have cellular immunodeficiency or humoral immune defects, severe cases may have combined immunodeficiency. These congenital and secondary immune defects, the body of foreign pathogens can not produce a normal immune response, can not prevent the invasion of pathogens on the body and control the development of the disease. Therefore, repeated infection or severe infection has become the most obvious clinical manifestations of immunodeficiency in children, but also the main cause of death.