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研究目的是提高脂质体的稳定性，延长在血循环中的时间，增强在非ＲＥＳ部位的靶向性。将不同分子量的ＰＥＧ－ＰＥ（聚乙二醇单甲醚磷脂酰乙醇胺衍生物）掺入脂质体，比较其在体外的稳定性和体内的分布情况。结果表明，该类脂质体在血循环中的滞留时间显著延长。并且与ＰＥＧ的分子量有密切关系。本研究方法简便易行，从而省去同位素标记的困难，具有良好的应用前景。
The purpose of the study was to increase the stability of liposomes, prolong the time in blood circulation and enhance the targeting of non-RES sites. PEG-PE (polyethylene glycol monomethyl ether phosphatidylethanolamine derivatives) of different molecular weight was incorporated into the liposomes to compare their in vitro stability and in vivo distribution. The results showed that the liposomes in the blood circulation in the residence time significantly longer. And the molecular weight of PEG is closely related. The research method is simple and easy, thus eliminating the difficulty of isotope labeling and has good application prospects.