论文部分内容阅读
选择我院住院及门诊尿常规检查蛋白阴性的 2型糖尿病患者 5 0 0例 ,糖尿病病程 2个月～ 5年。采用酶免疫法测定 2 4小时尿蛋白排泄率 (VAER)、尿微量白蛋白 (UAC)、尿转铁蛋白 (UTC)。 VAER为 2 0～ 2 0 0μg/m in患者 12 0例 ,排除其他原因所致的蛋白尿 ,诊断为早期糖尿病肾病或糖尿病肾病微量白蛋白尿期。以 VAER为金标准 ,计算 UAC、U TC在不同截断点时的敏感度和特异度 ,根据 ROC曲线确定最佳截断点 ,并比较这两项检查在糖尿病肾病筛选中的价值。结果 :U AC最佳截断点为 2 0 m g/ L,敏感度为 83.3%,特异度为 92 .1%;UTC最佳截断点为 1mg/ L ,敏感度为 91.7%,特异度为 89.5 %。认为 ,随机尿 UAC和 UTC在早期糖尿病肾病筛选中的敏感度和特异度均较高 ,UTC比 UAC有更高的敏感度 ,但特异度较前者差
Select our hospital and outpatient urine routine examination of protein-negative type 2 diabetes patients 500 cases, duration of diabetes 2 months to 5 years. 24-hour urinary protein excretion rate (VAER), urine microalbuminuria (UAC) and urinary transferrin (UTC) were measured by enzyme immunoassay. VAER was 20 ~ 200 μg / m in 120 patients, excluding other causes of proteinuria, diagnosis of early diabetic nephropathy or diabetic nephropathy microalbuminuria. Using VAER as the gold standard, the sensitivity and specificity of UAC and U TC at different cut-off points were calculated. The best cut-off point was determined by ROC curve and the value of these two tests was compared in the screening of diabetic nephropathy. Results: The best cutoff point of U AC was 20 mg / L, the sensitivity was 83.3% and the specificity was 92.1%. The best cutoff point of UTC was 1 mg / L, the sensitivity was 91.7% and the specificity was 89.5% . That the random urine UAC and UTC in the early screening of diabetic nephropathy sensitivity and specificity are higher, UTC than UAC have a higher sensitivity, but the specificity is worse than the former