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背景及目的:外阴上皮内瘤样变是由高风险人乳头状瘤病毒(HPV),主要是HPV-16导致的慢性病变。只有不到1.5%的患者可自愈,而且治疗后的复发率很高。本研究评价了合成性、含有不完全弗氏佐剂的抗HPV-16癌基因蛋白E6和E7的长肽疫苗对HPV-16阳性、外阴上皮高度内瘤样变妇女的免疫原性和有效性。
BACKGROUND AND AIM: Vulvar intraepithelial neoplasia is a chronic disease caused by high-risk human papilloma virus (HPV), mainly HPV-16. Fewer than 1.5% of patients are self-healing and have a high recurrence rate after treatment. This study evaluated the immunogenicity and effectiveness of synthetic, long peptide vaccines against human papillomavirus 16 (HPV16) positive and vulvar epithelial tumor endothelium-like transformation with incomplete Freund’s adjuvant anti-HPV-16 oncogene proteins E6 and E7 .