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目的探讨一氧化氮合成酶同功酶（NOS）在急性肾炎发病过程中的组织分布情况。方法我们应用免疫组化技术对大鼠肾脏三种一氧化氮合成酶同功酶分别进行了组织定位和活性比较观察。结果发现病理情况下诱导型一氧化氮合成酶活性明显增加，其广泛分布于肾脏组织管腔上皮细胞，而且各种一氧化氮合成酶同功酶在肾组织的分布位置亦有一定的差别。结论在急性肾炎发病过程中肾脏组织诱导型一氧化氮合成酶被大量合成是造成机体一氧化氮升高的直接原因。
Objective To investigate the tissue distribution of nitric oxide synthase isoenzyme (NOS) in the pathogenesis of acute nephritis. Methods We used immunohistochemistry to observe the localization and activity of three nitric oxide synthase isoenzymes in rat kidney respectively. The results showed that the pathological changes of inducible nitric oxide synthase activity was significantly increased, which is widely distributed in the renal lumen epithelial cells, and a variety of nitric oxide synthase isoenzyme in the distribution of kidney tissue there are some differences. Conclusion The synthesis of inducible nitric oxide synthase in the kidney during the pathogenesis of acute nephritis is the direct cause of the increase of nitric oxide in the body.