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目的:观察清肝益气降压方配伍针刺太冲、太溪、足三里对高血压大鼠血压、血浆内皮素、血清一氧化氮的影响,探讨方药和针刺不同穴位的交互作用及其内在的机理。方法:采用正交设计安排实验,将造模成功大鼠分别给予清肝益气降压方和针刺,连续治疗2周后,测定大鼠血压、血浆内皮素、血清一氧化氮。结果:清肝益气降压方配伍针刺能使ET含量降低,NO含量升高,使血压降低,优于单纯针刺和方药组(P<0.05)。结论:针刺和药物间产生协同作用,可以按照中医辨证施治原则配伍使用。针刺和方药对各项指标的影响程度不一,可能这种多靶点、多途径、多层次的作用方式,是针药产生协同作用的基本原因。
Objective: To observe the effects of qi, liver and qi, blood pressure side compatibility acupuncture Tai-chong, Tai-chi, Zusanli on blood pressure, plasma endothelin, serum nitric oxide, and explore the interaction between acupuncture and acupuncture points and Its inherent mechanism. Methods: Orthogonal design was used to arrange the experiment. The rats of successful model were given Qinggan Yiqi Jiangya Prescription and acupuncture respectively. After two weeks continuous treatment, the blood pressure, plasma endothelin and serum nitric oxide were determined. Results: Liver-qi and blood-pressure-reducing prescription combined with acupuncture can reduce the content of ET, increase the content of NO and decrease the blood pressure, which is better than that of the simple acupuncture and the prescription group (P <0.05). Conclusion: The synergy between acupuncture and medicine can be used in accordance with the principles of TCM syndrome differentiation. Acupuncture and prescription drugs on the various indicators of varying degrees, it may be multi-target, multi-channel, multi-level mode of action, synergy acupuncture drugs are the basic causes.