炎症性肠病(inflammatory bowel disease,IBD)是一种病因和发病机制尚不清楚的肠道慢性炎症性疾病,且尚无疗效确切的根治方法,因此成为研究的热点和难点。一般认为免疫调节紊乱是关键的发病机制~([1-3])。已知CD4~+T细胞在免疫反应中起重要调节作用,IBD病变局部总有CD4~+T细胞的浸润并表现出异常的功能状态,其中最主要的是辅助性CD4~+T细胞。因此有理由认为辅助性CD4+T细 Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal tract whose etiology and pathogenesis are not clear. There is no definite curative effect and it has become a hot and difficult point of study. It is generally believed that immune disorder is the key pathogenesis ~ ([1-3]). CD4 ~ + T cells are known to play an important regulatory role in the immune response. In patients with IBD, CD4 ~ + T cells are always infiltrated and show abnormal functional status. The most important one is CD4 + T cells. So there is reason to think that helper CD4 + T cells