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本研究采用离体大鼠肺动脉环,借助特异性一氧化氮(NO)合酶(NOS)抑制剂LNAME研究川芎嗪(LT)舒血管作用机制,为LT在临床上更为广泛的应用提供理论依据。材料与方法 雄性Wistar大鼠重180~260g,断头处死,速开胸取心肺组织置0℃Kreb?
In this study, rat pulmonary artery rings were used to study the vasorelaxation mechanism of tetramethylpyrazine (LT) with the help of specific nitric oxide synthase (NOS) inhibitor L NAME, which is a more widely used clinical application of LT. Provide theoretical basis. Materials and Methods Male Wistar rats weighing 180-260g were sacrificed by decapitation. Cardiopulmonary tissue at 0°CKreb was obtained by rapid thoracotomy.