维生素E(VE)是生物抗氧化剂,具有重要的生理和药理作用,因此被广泛应用于临床。最近,Boscoboinik等发现,VE还可抑制细胞增殖,这可能是通过非抗氧化途径实现的。他们研究了VE对培养的大鼠主动脉平滑肌细胞(VSMC)、人的骨肉瘤细胞、成纤维细胞和神经母细胞瘤细胞增殖抑制作用,其中对VSMC的增殖抑制作用最为明显。在培养基中加入血小板衍生因子(PDGF)和内皮素(ET)可使[~3H]-胸腺嘧啶核苷掺入VSMC的量及细胞数量明显增加,此增殖效应可被α-生育酚 Vitamin E (VE) is a bio-antioxidant, has important physiological and pharmacological effects, it is widely used in clinical. Recently, Boscoboinik and other found that VE can also inhibit cell proliferation, which may be achieved through the non-antioxidant pathways. They studied the inhibitory effect of VE on the proliferation of rat aortic smooth muscle cells (VSMCs), human osteosarcoma cells, fibroblasts and neuroblastoma cells, with the most significant inhibition of VSMC proliferation. Addition of platelet-derived factor (PDGF) and endothelin (ET) to culture medium resulted in a significant increase in the amount and number of [~ 3H] -thymidine incorporation into VSMC, which could be induced by α-tocopherol