[Objective] To discuss the protection and regulatory effects of Yupingfeng polysaccharides on mice with immune function damage.[Methods]The immunosuppressive mice mode was established by 80 mg/kg cyclophosphamide. Effects of different dosages of Yupingfeng polysaccharides( 150,300,600 mg / kg) on structure and function recovery of mice immune organs were observed. [Results]The thymus and spleen in mice enlarged significantly; spleen index of mice increased obviously; splenic lymphocyte proliferation and transformation capacitates and NK cell activity all increased significantly( P < 0. 05 or P < 0. 01). Besides,spleen structure was damaged with compensatory hyperplasia of lymphoid tissue. Observation of polysaccharides positive control group( no administration of cyclophosphamide) showed that after mice were stimulated by Yupingfeng polysaccharides,spleens showed structural hyperplasia and hypertrophy. [Conclusions]Yupingfeng polysaccharides significantly promoted the structural and functional compensation of spleen after immunosuppression,and had obvious enhancement effects on spleen functions of normal mice. [Methods] The immunosuppressive mice mode was established by 80 mg / kg cyclophosphamide. Effects of different dosages of Yupingfeng polysaccharides (150,300,600 mg / kg) on [Results] The thymus and spleen in mice enlarged significantly; spleen index of mice increased obviously; splenic lymphocyte proliferation and transformation capacitates and NK cell activity all increased significantly (P <0.05 or Observation of polysaccharides positive control group (no administration of cyclophosphamide) showed that after mice were stimulated by Yupingfeng polysaccharides, spleens showed structural hyperplasia and hypertrophy. [P <0. 01). Conclusions] Yupingfeng polysaccine significantly promoted the structural and fu nctional compensation of spleen after immunosuppression, and had obvious enhancement effects on spleen functions of normal mice.