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目的分析甘精胰岛素联合降糖药物口服作用于老年2型糖尿病治疗中的有效性。方法将2014年7月-2016年8月在深圳市人民医院接受治疗的73例老年2型糖尿病患者作为研究对象。通过双盲法将患者分为观察组37例和对照组36例,对照组在二甲双胍治疗基础上给予磺脲类药物治疗,观察组在对照组基础上加入甘精胰岛素,比较两组治疗有效率和低血糖发生率。结果经治疗,观察组治疗总有效率为91.89%,高于对照组的80.56%,差异有统计学意义(P<0.05),观察组低血糖发生率为24.32%,对照组低血糖发生率为22.22%,比较差异无统计学意义(P>0.05)。结论甘精胰岛素与降糖药物联合治疗老年2型糖尿病患者,效果优于降糖药物单独使用并无明显增加低血糖发生率,整体效果更为理想,值得在临床借鉴和推广。
Objective To analyze the efficacy of insulin glargine combined with hypoglycemic agents in the treatment of type 2 diabetes in the elderly. Methods A total of 73 elderly patients with type 2 diabetes treated in Shenzhen People’s Hospital from July 2014 to August 2016 were selected as the study subjects. The patients were divided into observation group (37 cases) and control group (36 cases) by double-blind method. The control group was treated with sulfonylureas on the basis of metformin treatment. The observation group was added glargine on the basis of the control group. And the incidence of hypoglycemia. Results After treatment, the total effective rate in the observation group was 91.89%, which was higher than that in the control group (80.56%), the difference was statistically significant (P <0.05). The incidence of hypoglycemia in the observation group was 24.32% 22.22%, the difference was not statistically significant (P> 0.05). Conclusion Combination of insulin glargine and hypoglycemic agents in elderly patients with type 2 diabetes mellitus is superior to hypoglycemic agents alone in the incidence of hypoglycemia. The overall effect is more ideal and worthy of clinical reference and promotion.