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目前认为气道变态反应性炎症(AAI)是哮喘,尤其是迁延性、慢性哮喘最重要的病理基础。积极寻找皮质激素以外的“抗AAI’类抗炎药,是治疗哮喘的重要方面。近年来认为磷脂酶A_2抑制剂有减少炎症介质释放,从而减轻气道炎症的作用,氯喹就属于这一类药物。我们应用氯喹雾化剂治疗哮喘21例,报告如下。 材料和方法 37例哮喘患者均符合中华医学会制订的哮喘诊断标准,为常年间歇发作、病情属中或轻度患者。其中30例曾作皮肤变态反应,22例对2～4种吸入过敏原呈阳性反应。37例分为两组:治疗组21例,吸入1％氯喹水溶液;16例仅吸入生理盐水为对照组。其他合并用药基本一致,37例均用氨茶碱0.4～0.6/d,或喘定0.8～1.0/d,舒喘灵9.6～14.4mg/d。治疗组中11例,对照组中8例并用强的松15～20mg/d。治疗前一周停用各种雾化用药。治疗观察期间随症状好转减用合并用药。本组无半途加用其它平喘药者。
Currently, airway allergic inflammation (AAI) is considered to be the most important pathological basis for asthma, especially persistent and chronic asthma. Actively looking for anti-corticosteroids outside the class of “anti-AAI” anti-inflammatory drugs, is an important aspect of the treatment of asthma.In recent years that phospholipase A 2 inhibitors have to reduce the release of inflammatory mediators, thereby reducing the role of airway inflammation, chloroquine belongs to this category Drugs.We use chloroquine atomization agent in the treatment of 21 cases of asthma, the report is as follows.Materials and methods 37 cases of asthma patients are in line with the Chinese Medical Association to develop asthma diagnostic criteria for intermittent seizures, the disease is moderate or mild patients, of which 30 cases Twenty-two cases were positive for 2-4 inhaled allergens, and were divided into two groups: 21 in the treatment group, 1% chloroquine inhalation solution, 16 injections of normal saline as the control group, and other combinations The medication was basically the same, 37 cases were treated with aminophylline 0.4 ~ 0.6 / d, or asthma 0.8 ~ 1.0 / d, salbutamol 9.6 ~ 14.4mg / d in the treatment group, 11 cases, 8 cases in the control group Loose 15 ~ 20mg / d. Disable a variety of nebulization medication the week before treatment .With the improvement of symptoms during the treatment of observation combined with medication .This group no half-way plus other antiasthmatic agents.