本文研究在健康的青年和老年受试者中,食物对萘普生控释片剂在胃肠道中滞留时间的影响。选择男女受试者各6名,年龄20～76岁,体重56～88kg。在实验前二周禁止使用药物,实验采用控释骨架片,含萘普生1g和少量离子交换树脂(Amberlite IR-120(H))粉末,以1MBq铟-111作放射标记。片剂的面积为17×4mm,缓慢蚀介释放萘普生,每日服药1次。 This article investigates the effect of food on the residence time of naproxen controlled release tablets in the gastrointestinal tract in healthy young and elderly subjects. Six male and female subjects were selected, aged 20-76 years old, weighing 56-88kg. Two weeks before the experiment, the drug was banned. The controlled release matrix tablets containing 1 g of Naproxen and a small amount of ion exchange resin (Amberlite IR-120 (H)) powder were radiolabeled with 1 MBq indium-111. Tablet area of ​​17 × 4mm, naproxen slowly release ethion, medication 1 times a day.