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目的探讨牛磺酸时于四氯化碳所致小鼠急性肝脏毒性的解毒作用．方法４０只昆明小鼠（体重２０±１ｇ．雄性），随机分为对照组和实验组，实验组通过预防性给予牛磺酸５０ｍｇ·ｋｇ－１×１４ｄ，对照组同期给予等量０．９％ＮＳ．ｄ１４两组同时经腹脏注射四氯化碳４ｍｌ·ｋｇ－１记时，观察注射后动物表现及死亡时间作病理切片观察．结果牛碳酸预防性给药，对于四氯化碳所致肝脏毒性有明显的桔抗作用，可明显延长中毒小鼠的生存时间．对四氯化碳所致肝细胞脂肪变性．肝细胞肿大及坏死有一定的保护作用．与时照组相比牛磺酸组动物肝脏变性坏死灶较小，肝脏肿大也较轻．结论牛磺酸在一定程度上具有解除肝脏细胞毒性的作用，可作为一种肝脏细胞保护因子用于临床．１
4. Objective To investigate the detoxification effect of taurine on carbon tetrachloride induced acute liver toxicity in mice. Methods Forty Kunming mice (body weight 20±1g. male) were randomly divided into control group and experimental group. The experimental group was given taurine 50 mg·kg-1×14 d by prophylactic administration, while the control group was given equal 0.9 at the same time. %NS. When d14 was injected intraperitoneally with carbon tetrachloride (4ml·kg-1), the performance of the animals and the time of death were observed for pathological sections. Results Prophylactic administration of bovine carbonic acid had significant anti-hepatitis effect on hepatotoxicity induced by carbon tetrachloride, which significantly prolonged the survival time of poisoned mice. Hepatocellular steatosis caused by carbon tetrachloride. Liver cell swelling and necrosis have a protective effect. Compared with the control group, the taurine group had smaller liver necrosis and necrosis and hepatic enlargement. Conclusion Taurine can relieve liver cytotoxicity to a certain extent, and it can be used as a hepatocyte protective factor in clinical practice. 1