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某患者因牙周炎来诊,作牙周洁治后,给甲硝唑顿服0.4g tid。次晨双手指麻木、痒,又服2次,反应加重,引起口唇麻木又来诊,检查患者双手手指和口唇部可见散在粟粒大小充血性丘疹,血液化检除嗜酸粒细胞略高外其余正常,嘱停服甲硝唑。加扑尔敏8mg、地塞米松15mgtid,麻木和丘疹症状逐渐消失,出现反应前未使用其他药物及致敏食物,考虑为甲硝唑的致敏反应。 (编者按:要确诊甲硝唑过敏,应进一步做致敏试验证实)
A patient due to periodontitis to diagnosis, for periodontal clean, to metronidazole Dayton serving 0.4g tid. Second morning refers to the numbness of the fingers, itchy, and served 2 times, the reaction worsened, numb lips and mouth again to check the patient’s hands and fingers and lips visible scattered miliary size congestive papules, blood eosinophils slightly higher than the remaining Normal, asked to stop taking metronidazole. Plus chlorpheniramine 8mg, dexamethasone 15mgtid, numbness and pimple symptoms gradually disappear before the reaction did not use other drugs and sensitized food, consider the sensitization of metronidazole. (Editor’s note: To confirm the metronidazole allergy, allergy test should be further confirmed)