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病例和方法作者在1981～1985年2300例住院患者中观察到8例患者(0.3%)血清肌酐浓度异常降低[<40μmol/1L(<0.5mg/dl)]。8例患者均为重症肝病,其中7例暴发性肝炎,1例晚期原发性胆汁性肝硬化。7例患者血清尿酸盐浓度降低,4例有低钠血症。所有患者的治疗均不影响肾小管的尿酸盐或肌酐转运,且均静脉输注大量液体(>2000ml/d)和新鲜冻干血浆(160～400ml/d)。每例在血清肌酐降低之前出现多尿症。作者测定了8例患者24小时内生肌酐清除率,并于血清肌酐水平异常降低时测定
Case and Method The authors observed abnormal reductions in serum creatinine concentrations in 8 patients (0.3%) from 2,300 inpatients between 1981 and 1985 [<40 μmol / 1L (<0.5 mg / dl)]. All 8 patients were severe liver disease, including 7 cases of fulminant hepatitis and 1 case of advanced primary biliary cirrhosis. Serum urate concentration decreased in 7 patients and hyponatremia in 4 patients. None of the patients treated had tubule urate or creatinine transfusions, and a large volume of fluid (> 2000 ml / d) and fresh lyophilized plasma (160-400 ml / d) were infused intravenously. Polyuria occurred before each decrease in serum creatinine. The authors measured endogenous creatinine clearance in 8 patients over a 24-hour period and were measured when the serum creatinine level was abnormally decreased