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脑啡肽是新近发现的一种内源性的多肽,它和吗啡一样具有镇痛作用,因此也称为内源性的吗啡样物质。给19只清醒的大鼠脑室注射200微克/10微升的甲硫氨酸脑啡肽(methionine enkephalin)后发现:有8只鼠出现镇痛效应;有15只出现异常的癫痫样的脑电图发作,一般可持续3分钟,有些动物可长达1小时以上。异常脑电图最初表现为快速的反复发作的棘波,约持续20～30秒钟;以后转变为每秒4～6次高幅尖波;30分钟后转变为低幅的去同步的脑电图;最后转变为每5～7秒钟1次的反复出现的棘波。在此期间动物很少自发运动,但有阵发性的抽搐和湿
Enkephalin is a recently discovered endogenous peptide that has the analgesic effect of morphine and is therefore also known as endogenous morphine-like substance. Nineteen awake rats were injected intracerebroventricularly with 200 micrograms / 10 microliters of methionine enkephalin and found that eight rats had analgesic effects; 15 had epileptiform EEG Figure attack, the general sustainable 3 minutes, some animals can be up to 1 hour or more. Abnormal EEG initially manifested as rapid recurrent spikes, lasted about 20 to 30 seconds; later converted to 4 to 6 times per second high amplitude spikes; 30 minutes later transformed into a low amplitude of the brain electrical synchronization Figure; finally transformed into a repeated every 5 to 7 seconds spikes. Animals rarely spontaneously moved during this period, but had paroxysmal convulsions and wetness