目的：观察华蟾治疗乙型肝炎的疗效。方法：将１１０例慢性乙型肝炎患者随机分成两组进行药效对比观察。一组５０例采用常规保肝药物治疗为对照组，另一组在常规药物治疗基础上加用华蟾素注射液治疗为治疗组，两组在年龄、性别、病情上大致相同，有可比性。结果：治疗组在ＨＢｅＡｇ、ＨＢＶＤＮＡ转阴上优于对照组（Ｐ＜０．０５）。结论：华蟾素具有清除乙肝病素作用，近期疗效优于常规保肝药 Objective: To observe the curative effect of Chinese toad treatment of hepatitis B. Methods: 110 patients with chronic hepatitis B were randomly divided into two groups for comparative efficacy. A group of 50 patients treated with conventional hepatoprotective drugs as the control group, the other group on the basis of conventional drug therapy with cinobufacini injection treatment for the treatment group, the two groups in age, gender, the disease is about the same, comparable . Results: The treatment group was better than the control group in HBeAg and HBVDNA negative (P <0.05). Conclusion: Cinobufotalin has the effect of clearing hepatitis B, and the recent curative effect is better than that of conventional hepatoprotective drugs